Similac® Human Milk Fortifier Extensively Hydrolyzed Protein Concentrated Liquid

SIMILAC^® HUMAN MILK FORTIFIER EXTENSIVELY HYDROLYZED PROTEIN CONCENTRATED LIQUID

For preterm or low-birth-weight infants

For preterm or low-birth-weight infants nourished with human milk that requires fortification to meet elevated nutrient requirements. Intended as a nutritional supplement to add to human milk. For oral or tube feeding use. Use under medical supervision.

Download Product Guide (PDF 113 KB)

Availability

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

LIST NUMBER

ITEM

63010

Similac^® Human Milk Fortifier Concentrated Liquid; 5-mL packets; 24 x 6 /case

Features

Commercially sterile liquid:
- A safer choice for preterm and low-birth-weight infants;^1,2,3
- Preferred for even distribution during mixing;³
- Heat treated for sterility (non-acidified product).
Concentrated to minimize displacement; each packet displaces 5 mL.^*
Extensively hydrolyzed protein for easy digestion and absorption.
When added to human milk, meets expert recommendations for protein^* and other nutrients for the preterm infant.^4,5
Clinically proven to support weight, length and head circumference gains in preterm babies.^6,7,8
Safe and well tolerated by preterm infants.^6,7,8
Contains an exclusive blend of DHA, lutein and natural vitamin E^†, all found in the infant brain and eyes.^9,10,11,12
Low iron content provides flexibility to add iron as needed.
Gluten-free.

PRECAUTIONS

This product is nutritionally incomplete by itself and is designed to be added to human milk.
Add only to human milk - do not add water.
Never use a microwave oven to warm fortified human milk; serious burns can result. Test temperature before feeding to avoid scalding the baby’s mouth.
Follow label instructions when using this product. Abbott has not evaluated this product to fortify human milk in a clinical trial at energy densities greater than 24 Cal/30 mL (81 Cal/100 mL). Therefore, the occasional use of a higher energy density should be done under strict medical supervision.
Additional iron may be necessary.
Tolerance to enteral feedings should be confirmed by offering small volumes of unfortified human milk.
Once enteral feeding is well established, Similac® Human Milk Fortifier Extensively Hydrolyzed Protein Concentrated Liquid can be added to human milk.
Not intended for feeding low-birth-weight infants after they reach a weight of 3600 g (approximately 8 lb) or as directed by a health care professional.
Not for parenteral use.

^* One packet mixed with 25 mL of human milk.

¹ Government of Canada. Preparing and handling powdered infant formula. Last modiﬁed on 2021-04-16. [Accessed online on 2021-05-30].

^† RRR-alpha-tocopherol, the most bioactive form of vitamin E.

² Centers for Disease Control and Prevention. Cronobacter Infection and Infants. Last reviewed on 2021-02-08. [Accessed online on 2021-07-06].

³ Pediatric Nutrition Practice Group. Steele C, Collins E (eds). Infant and Pediatric Feedings: Guidelines for Preparation of Human Milk and Formula in Health Care Facilities, 3rd Ed. Academy of Nutrition and Dietetics. 2019:12.

⁴ Koletzko B, et al. Nutritional Care of Preterm Infants. Scientific Basis and Practical Guidelines. World Rev Nutr Diet. Basel, Karger, 2021, vol 122 pp 191-197.

⁵ Embleton ND, et al. JPGN 2022;76:248–268.

⁶ Kim JH, et al. J Pediatr Gastroenterol Nutr. 2015;61-665-71.

⁷ Kumar N, et al. Am J Perinatol. 2017;34(14):1411-6.

⁸ Schanler RJ, et al. J Pediatr. 2018;202:31-7.

⁹ Krinsky NI, et al. Annu Rev Nutr. 2003;23:171-201.

¹⁰ Vishwanathan R, et al. JPGN. 2014;59(5):659-65.

¹¹ Kuchan MJ, et al. Br J Nutr. 2016;116(1):126-31.

¹² Kuchan MJ, et al. Curr Dev Nutr. 2018;2:nzy055

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Preparation

Directions for Use:

USE AS DIRECTED BY A HEALTH CARE PROFESSIONAL.
ADD ONLY TO HUMAN MILK. DO NOT ADD WATER.

This human milk fortifier is formulated for preterm and low-birth-weight infants as a nutritional supplement to be added to human milk. Proper hygiene, handling and storage are important when preparing fortified human milk. Failure to follow these directions could result in severe harm.

Pour desired quantity of human milk into sterile feeding container.
Product separation is normal. Massage contents until uniform.
To open packet, tear top off completely along perforation.
Add fortifier to human milk and gently shake until mixed well.
Use or refrigerate immediately.
- Bottle feeding: Discard 1 hour after feeding begins.
- Tube feeding: Limit hang time to a maximum of 4 hours.

Use immediately or store unused fortified human milk in the refrigerator; use within 24 hours or according to hospital procedures for handling human milk.
After refrigeration, remix gently if needed and feed promptly.
Store unopened packets at room temperature in this protective carton; avoid extreme temperatures.

Similac Human Milk Fortifier Extensively Hydrolyzed Protein Concentrated Liquid (HMF HP CL) Mixing Chart

	Additional Cal Desired	Preterm Human Milk	Similac HMF HP CL
For Initiation	2 Cal/30 mL	50 mL	1 packet (0.9 g)
For Full Strength Feeding	4 Cal/30 mL	25 mL	1 packet (0.9 g)

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Nutrition

Unflavored Concentrated Liquid

Similac^®Human Milk Fortifier Concentrated Liquid; 5-mL packets; 24 x 6 /case

Serving size: 1 packet (5 mL)

Value

Product Characteristics

Caloric Density (Cal/mL)
0.8

Protein (% of total energy)
29.3

Protein Source
Casein hydrolysate

Fat (% of total energy)
26.7

MCT oil (% of total fats)
44.9

Omega-6:Omega-3 Ratio
4.5:1

Fat Source
MCT oil, soy oil, coconut oil, M. alpina, C. cohnii oil

Carbohydrate (% of total energy)
44

Carbohydrate Source
Corn maltodextrin, modiﬁed corn starch

Total Cal:g Nitrogen Ratio
85:1

Nonprotein Cal:g Nitrogen Ratio
60:1

Water (g/30 mL)
25.3

Osmolality (mOsm/kg water)
450^*

Renal Solute Load (mOsm/L)
256^*

Recommended Tube Size for Gravity/Pump Feeding (Fr)
N/A

^* Value based on 25 mL of Preterm Human Milk + 1 packet of Similac® Human Milk Fortifier Extensively Hydrolyzed Protein Concentrated Liquid.

Amount per Serving

Nutrient Data

ENERGY, Cal (kJ)
7 (29)

Protein, g
0.50

Carnitine, mg
0.48

Leucine, mg
35

Tyrosine, mg
7.3

Tryptophan, mg
4.5

Fat, g
0.21

Linoleic Acid, g
0.018

Linolenic Acid, g
0.0022

Arachidonic Acid (ARA), g
0.0043

Docosahexaenoic Acid (DHA), g
0.003

Carbohydrate, g
0.75

Vitamins

Vitamin A, IU
197

Vitamin D, IU
35

Vitamin E, IU
1.0

Vitamin K, mg
0.0024

Vitamin C, mg
7.7

Thiamine, mg
0.048

Riboflavin, mg
0.074

Niacin, mg
0.98

Vitamin B6, mg
0.05

Folic Acid, mg
0.007

Vitamin B12, mg
0.00013

Pantothenic Acid, mg
0.31

Biotin, mg
0.0058

Choline, mg
0.9

Inositol, mg
1.7

Lutein, mg
0.00306

Minerals

Sodium, mg
5

Potassium, mg
21

Chloride, mg
13

Calcium, mg
30

Phosphorus, mg
17

Magnesium, mg
2.1

Iron, mg
0.11

Zinc, mg
0.31

Iodine, mg
0.0004

Copper, mg
0.015

Manganese, mg
0.0022

Selenium, mg
0.0002

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Ingredients

Unflavored Concentrated Liquid

Similac^® Human Milk Fortifier Concentrated Liquid; 5-mL packets; 24 x 6 /case

Water, Corn Maltodextrin, Casein Hydrolysate (Milk), Modiﬁed Coconut and/or Palm Kernel Oils (Medium Chain Triglycerides), Calcium Phosphate, Modified Corn Starch, Soy Oil, Coconut Oil, Potassium Citrate, Ascorbic Acid, Magnesium Chloride, M. Alpina Oil (A Source Of ARA), C. Cohnii Oil (A Source Of DHA), Potassium Hydroxide, Potassium Chloride, Salt, L-Tyrosine, L-Leucine, Monoglycerides, M-Inositol, L-Tryptophan, Choline Chloride, Niacinamide, Zinc Sulphate, D-Alpha-Tocopheryl Acetate, Gellan Gum, L-Carnitine, Calcium D-Pantothenate, Ferrous Sulphate, Vitamin A Palmitate, Thiamine Chloride Hydrochloride, Pyridoxine Hydrochloride, Riboflavin, Vitamin D3, Cupric Sulphate, Folic Acid, Biotin, Manganese Sulphate, Lutein, Phylloquinone, Beta-Carotene, Sodium Selenite, Cyanocobalamin, and As Needed: Potassium Phosphate.

Contains: Milk.

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Availability

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

LIST NUMBER

ITEM

63010

Similac^® Human Milk Fortifier Concentrated Liquid; 5-mL packets; 24 x 6 /case

Features

Commercially sterile liquid:
- A safer choice for preterm and low-birth-weight infants;^1,2,3
- Preferred for even distribution during mixing;³
- Heat treated for sterility (non-acidified product).
Concentrated to minimize displacement; each packet displaces 5 mL.^*
Extensively hydrolyzed protein for easy digestion and absorption.
When added to human milk, meets expert recommendations for protein^* and other nutrients for the preterm infant.^4,5
Clinically proven to support weight, length and head circumference gains in preterm babies.^6,7,8
Safe and well tolerated by preterm infants.^6,7,8
Contains an exclusive blend of DHA, lutein and natural vitamin E^†, all found in the infant brain and eyes.^9,10,11,12
Low iron content provides flexibility to add iron as needed.
Gluten-free.

PRECAUTIONS

This product is nutritionally incomplete by itself and is designed to be added to human milk.
Add only to human milk - do not add water.
Never use a microwave oven to warm fortified human milk; serious burns can result. Test temperature before feeding to avoid scalding the baby’s mouth.
Follow label instructions when using this product. Abbott has not evaluated this product to fortify human milk in a clinical trial at energy densities greater than 24 Cal/30 mL (81 Cal/100 mL). Therefore, the occasional use of a higher energy density should be done under strict medical supervision.
Additional iron may be necessary.
Tolerance to enteral feedings should be confirmed by offering small volumes of unfortified human milk.
Once enteral feeding is well established, Similac® Human Milk Fortifier Extensively Hydrolyzed Protein Concentrated Liquid can be added to human milk.
Not intended for feeding low-birth-weight infants after they reach a weight of 3600 g (approximately 8 lb) or as directed by a health care professional.
Not for parenteral use.

^* One packet mixed with 25 mL of human milk.

¹ Government of Canada. Preparing and handling powdered infant formula. Last modiﬁed on 2021-04-16. [Accessed online on 2021-05-30].

^† RRR-alpha-tocopherol, the most bioactive form of vitamin E.

² Centers for Disease Control and Prevention. Cronobacter Infection and Infants. Last reviewed on 2021-02-08. [Accessed online on 2021-07-06].

⁴ Koletzko B, et al. Nutritional Care of Preterm Infants. Scientific Basis and Practical Guidelines. World Rev Nutr Diet. Basel, Karger, 2021, vol 122 pp 191-197.

⁵ Embleton ND, et al. JPGN 2022;76:248–268.

⁶ Kim JH, et al. J Pediatr Gastroenterol Nutr. 2015;61-665-71.

⁷ Kumar N, et al. Am J Perinatol. 2017;34(14):1411-6.

⁸ Schanler RJ, et al. J Pediatr. 2018;202:31-7.

⁹ Krinsky NI, et al. Annu Rev Nutr. 2003;23:171-201.

¹⁰ Vishwanathan R, et al. JPGN. 2014;59(5):659-65.

¹¹ Kuchan MJ, et al. Br J Nutr. 2016;116(1):126-31.

¹² Kuchan MJ, et al. Curr Dev Nutr. 2018;2:nzy055

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Preparation

Directions for Use:

USE AS DIRECTED BY A HEALTH CARE PROFESSIONAL.
ADD ONLY TO HUMAN MILK. DO NOT ADD WATER.

Pour desired quantity of human milk into sterile feeding container.
Product separation is normal. Massage contents until uniform.
To open packet, tear top off completely along perforation.
Add fortifier to human milk and gently shake until mixed well.
Use or refrigerate immediately.
- Bottle feeding: Discard 1 hour after feeding begins.
- Tube feeding: Limit hang time to a maximum of 4 hours.

Use immediately or store unused fortified human milk in the refrigerator; use within 24 hours or according to hospital procedures for handling human milk.
After refrigeration, remix gently if needed and feed promptly.
Store unopened packets at room temperature in this protective carton; avoid extreme temperatures.

Similac Human Milk Fortifier Extensively Hydrolyzed Protein Concentrated Liquid (HMF HP CL) Mixing Chart

	Additional Cal Desired	Preterm Human Milk	Similac HMF HP CL
For Initiation	2 Cal/30 mL	50 mL	1 packet (0.9 g)
For Full Strength Feeding	4 Cal/30 mL	25 mL	1 packet (0.9 g)

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Nutrition

Unflavored Concentrated Liquid

Similac^®Human Milk Fortifier Concentrated Liquid; 5-mL packets; 24 x 6 /case

Serving size: 4 packets (20 mL)

Value

Product Characteristics

Caloric Density (Cal/mL)
0.8

Protein (% of total energy)
29.3

Protein Source
Casein hydrolysate

Fat (% of total energy)
26.7

MCT oil (% of total fats)
44.9

Omega-6:Omega-3 Ratio
4.5:1

Fat Source
MCT oil, soy oil, coconut oil, M. alpina, C. cohnii oil

Carbohydrate (% of total energy)
44

Carbohydrate Source
Corn maltodextrin, modiﬁed corn starch

Total Cal:g Nitrogen Ratio
85:1

Nonprotein Cal:g Nitrogen Ratio
60:1

Water (g/30 mL)
25.3

Osmolality (mOsm/kg water)
450^*

Renal Solute Load (mOsm/L)
256^*

Recommended Tube Size for Gravity/Pump Feeding (Fr)
N/A

^* Value based on 25 mL of Preterm Human Milk + 1 packet of Similac® Human Milk Fortifier Extensively Hydrolyzed Protein Concentrated Liquid.

Amount per Serving

Nutrient Data

ENERGY, Cal (kJ)
28 (116)

Protein, g
2.0

Carnitine, mg
1.92

Leucine, mg
140

Tyrosine, mg
29.2

Tryptophan, mg
18.0

Fat, g
0.84

Linoleic Acid, g
0.072

Linolenic Acid, g
0.0088

Arachidonic Acid (ARA), g
0.0172

Docosahexaenoic Acid (DHA), g
0.012

Carbohydrate, g
3.0

Vitamins

Vitamin A, IU
788

Vitamin D, IU
140

Vitamin E, IU
4.0

Vitamin K, mg
0.0096

Vitamin C, mg
30.8

Thiamine, mg
0.192

Riboflavin, mg
0.296

Niacin, mg
3.92

Vitamin B6, mg
0.2

Folic Acid, mg
0.028

Vitamin B12, mg
0.00052

Pantothenic Acid, mg
1.24

Biotin, mg
0.0232

Choline, mg
3.6

Inositol, mg
6.8

Lutein, mg
0.01224

Minerals

Sodium, mg
20

Potassium, mg
84

Chloride, mg
52

Calcium, mg
120

Phosphorus, mg
68

Magnesium, mg
8.4

Iron, mg
0.44

Zinc, mg
1.24

Iodine, mg
0.0016

Copper, mg
0.06

Manganese, mg
0.0088

Selenium, mg
0.0008

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Ingredients

Unflavored Concentrated Liquid

Similac^® Human Milk Fortifier Concentrated Liquid; 5-mL packets; 24 x 6 /case

Contains: Milk.

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Availability

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

LIST NUMBER

ITEM

Features

Commercially sterile liquid:
- A safer choice for preterm and low-birth-weight infants;^1,2,3
- Preferred for even distribution during mixing;³
- Heat treated for sterility (non-acidified product).
Concentrated to minimize displacement; each packet displaces 5 mL.^*
Extensively hydrolyzed protein for easy digestion and absorption.
When added to human milk, meets expert recommendations for protein^* and other nutrients for the preterm infant.^4,5
Clinically proven to support weight, length and head circumference gains in preterm babies.^6,7,8
Safe and well tolerated by preterm infants.^6,7,8
Contains an exclusive blend of DHA, lutein and natural vitamin E^†, all found in the infant brain and eyes.^9,10,11,12
Low iron content provides flexibility to add iron as needed.
Gluten-free.

PRECAUTIONS

This product is nutritionally incomplete by itself and is designed to be added to human milk.
Add only to human milk - do not add water.
Never use a microwave oven to warm fortified human milk; serious burns can result. Test temperature before feeding to avoid scalding the baby’s mouth.
Follow label instructions when using this product. Abbott has not evaluated this product to fortify human milk in a clinical trial at energy densities greater than 24 Cal/30 mL (81 Cal/100 mL). Therefore, the occasional use of a higher energy density should be done under strict medical supervision.
Additional iron may be necessary.
Tolerance to enteral feedings should be confirmed by offering small volumes of unfortified human milk.
Once enteral feeding is well established, Similac® Human Milk Fortifier Extensively Hydrolyzed Protein Concentrated Liquid can be added to human milk.
Not intended for feeding low-birth-weight infants after they reach a weight of 3600 g (approximately 8 lb) or as directed by a health care professional.
Not for parenteral use.

^* One packet mixed with 25 mL of human milk.

¹ Government of Canada. Preparing and handling powdered infant formula. Last modiﬁed on 2021-04-16. [Accessed online on 2021-05-30].

^† RRR-alpha-tocopherol, the most bioactive form of vitamin E.

² Centers for Disease Control and Prevention. Cronobacter Infection and Infants. Last reviewed on 2021-02-08. [Accessed online on 2021-07-06].

⁴ Koletzko B, et al. Nutritional Care of Preterm Infants. Scientific Basis and Practical Guidelines. World Rev Nutr Diet. Basel, Karger, 2021, vol 122 pp 191-197.

⁵ Embleton ND, et al. JPGN 2022;76:248–268.

⁶ Kim JH, et al. J Pediatr Gastroenterol Nutr. 2015;61-665-71.

⁷ Kumar N, et al. Am J Perinatol. 2017;34(14):1411-6.

⁸ Schanler RJ, et al. J Pediatr. 2018;202:31-7.

⁹ Krinsky NI, et al. Annu Rev Nutr. 2003;23:171-201.

¹⁰ Vishwanathan R, et al. JPGN. 2014;59(5):659-65.

¹¹ Kuchan MJ, et al. Br J Nutr. 2016;116(1):126-31.

¹² Kuchan MJ, et al. Curr Dev Nutr. 2018;2:nzy055

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Preparation

Directions for Use:

USE AS DIRECTED BY A HEALTH CARE PROFESSIONAL.
ADD ONLY TO HUMAN MILK. DO NOT ADD WATER.

Pour desired quantity of human milk into sterile feeding container.
Product separation is normal. Massage contents until uniform.
To open packet, tear top off completely along perforation.
Add fortifier to human milk and gently shake until mixed well.
Use or refrigerate immediately.
- Bottle feeding: Discard 1 hour after feeding begins.
- Tube feeding: Limit hang time to a maximum of 4 hours.

Use immediately or store unused fortified human milk in the refrigerator; use within 24 hours or according to hospital procedures for handling human milk.
After refrigeration, remix gently if needed and feed promptly.
Store unopened packets at room temperature in this protective carton; avoid extreme temperatures.

Similac Human Milk Fortifier Extensively Hydrolyzed Protein Concentrated Liquid (HMF HP CL) Mixing Chart

	Additional Cal Desired	Preterm Human Milk	Similac HMF HP CL
For Initiation	2 Cal/30 mL	50 mL	1 packet (0.9 g)
For Full Strength Feeding	4 Cal/30 mL	25 mL	1 packet (0.9 g)

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Nutrition

Preterm Human Milk

Serving size: 100 Cal

Value

Product Characteristics

Cal/30 mL
30^†

Protein (% of total energy)
N/A

Protein Source
Preterm human milk

Fat (% of total energy)
N/A

MCT oil (% of total fats)
N/A

Omega-6:Omega-3 Ratio
N/A

Fat Source
Preterm human milk

Carbohydrate (% of total energy)
N/A

Carbohydrate Source
Preterm human milk

Total Cal:g Nitrogen Ratio
N/A

Nonprotein Cal:g Nitrogen Ratio
N/A

Water (g/30 mL)
25.3

Osmolality (mOsm/kg water)
N/A

Renal Solute Load (mOsm/L)
N/A

^† The nutrient concentrations listed for preterm human milk are mean human milk levels. The range of nutrients in preterm human milk is highly variable (Meeting the Special Nutrient Needs of Low-Birth-Weight and Premature Infants in the Hospital (A8100). Columbus, Ohio: Abbott Nutrition, Abbott Laboratories, January 1998, p 56). Values for term human milk have been used for linoleic acid, biotin, choline, inositol, manganese, iodine, and selenium (American Academy of Pediatrics Committee on Nutrition: Pediatric Nutrition Handbook, 4th ed. Elk Grove Village: American Academy).

Amount per Serving

Nutrient Data

Energy, Cal
100^*

Protein, g
2.10

Volume, mL
149

Water, g
131

Fat, g
5.80

Linoleic Acid, g
0.550

Carbohydrate, g
9.90

Osmolality, mOsm/kg water
290

Potential Renal Solute Load, mOsm
18.7

Vitamins

Vitamin A, IU
581

Vitamin D, IU
3

Vitamin E, IU
1.6

Vitamin K, mg
0.0003

Vitamin C, mg
16.0

Thiamine, mg
0.031

Riboflavin, mg
0.072

Niacin, mg
0.224

Vitamin B6, mg
0.022

Folic Acid, mg
0.0049

Vitamin B12, mg
0.00007

Pantothenic Acid, mg
0.269

Biotin, mg
0.00060

Choline, mg
14.0

Inositol, mg
22.0

Minerals

Sodium, mg
37

Potassium, mg
85

Chloride, mg
82

Calcium, mg
37

Phosphorus, mg
19

Magnesium, mg
4.6

Iron, mg
0.18

Zinc, mg
0.51

Iodine, mg
0.016

Copper, mg
0.096

Manganese, mg
0.0009

Selenium, mg
0.0020

^* The nutrient concentrations listed for preterm human milk are mean human milk levels. The range of nutrients in preterm human milk is highly variable (Meeting the Special Nutrient Needs of Low-Birth-Weight and Premature Infants in the Hospital (A8100). Columbus, Ohio: Abbott Nutrition, Abbott Laboratories, January 1998, p 56). Values for term human milk have been used for linoleic acid, biotin, choline, inositol, manganese, iodine, and selenium (American Academy of Pediatrics Committee on Nutrition: Pediatric Nutrition Handbook, 4th ed. Elk Grove Village: American Academy).

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Ingredients

Preterm Human Milk

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Availability

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

LIST NUMBER

ITEM

Features

Commercially sterile liquid:
- A safer choice for preterm and low-birth-weight infants;^1,2,3
- Preferred for even distribution during mixing;³
- Heat treated for sterility (non-acidified product).
Concentrated to minimize displacement; each packet displaces 5 mL.^*
Extensively hydrolyzed protein for easy digestion and absorption.
When added to human milk, meets expert recommendations for protein^* and other nutrients for the preterm infant.^4,5
Clinically proven to support weight, length and head circumference gains in preterm babies.^6,7,8
Safe and well tolerated by preterm infants.^6,7,8
Contains an exclusive blend of DHA, lutein and natural vitamin E^†, all found in the infant brain and eyes.^9,10,11,12
Low iron content provides flexibility to add iron as needed.
Gluten-free.

PRECAUTIONS

This product is nutritionally incomplete by itself and is designed to be added to human milk.
Add only to human milk - do not add water.
Never use a microwave oven to warm fortified human milk; serious burns can result. Test temperature before feeding to avoid scalding the baby’s mouth.
Follow label instructions when using this product. Abbott has not evaluated this product to fortify human milk in a clinical trial at energy densities greater than 24 Cal/30 mL (81 Cal/100 mL). Therefore, the occasional use of a higher energy density should be done under strict medical supervision.
Additional iron may be necessary.
Tolerance to enteral feedings should be confirmed by offering small volumes of unfortified human milk.
Once enteral feeding is well established, Similac® Human Milk Fortifier Extensively Hydrolyzed Protein Concentrated Liquid can be added to human milk.
Not intended for feeding low-birth-weight infants after they reach a weight of 3600 g (approximately 8 lb) or as directed by a health care professional.
Not for parenteral use.

^* One packet mixed with 25 mL of human milk.

¹ Government of Canada. Preparing and handling powdered infant formula. Last modiﬁed on 2021-04-16. [Accessed online on 2021-05-30].

^† RRR-alpha-tocopherol, the most bioactive form of vitamin E.

² Centers for Disease Control and Prevention. Cronobacter Infection and Infants. Last reviewed on 2021-02-08. [Accessed online on 2021-07-06].

⁴ Koletzko B, et al. Nutritional Care of Preterm Infants. Scientific Basis and Practical Guidelines. World Rev Nutr Diet. Basel, Karger, 2021, vol 122 pp 191-197.

⁵ Embleton ND, et al. JPGN 2022;76:248–268.

⁶ Kim JH, et al. J Pediatr Gastroenterol Nutr. 2015;61-665-71.

⁷ Kumar N, et al. Am J Perinatol. 2017;34(14):1411-6.

⁸ Schanler RJ, et al. J Pediatr. 2018;202:31-7.

⁹ Krinsky NI, et al. Annu Rev Nutr. 2003;23:171-201.

¹⁰ Vishwanathan R, et al. JPGN. 2014;59(5):659-65.

¹¹ Kuchan MJ, et al. Br J Nutr. 2016;116(1):126-31.

¹² Kuchan MJ, et al. Curr Dev Nutr. 2018;2:nzy055

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Preparation

Directions for Use:

USE AS DIRECTED BY A HEALTH CARE PROFESSIONAL.
ADD ONLY TO HUMAN MILK. DO NOT ADD WATER.

Pour desired quantity of human milk into sterile feeding container.
Product separation is normal. Massage contents until uniform.
To open packet, tear top off completely along perforation.
Add fortifier to human milk and gently shake until mixed well.
Use or refrigerate immediately.
- Bottle feeding: Discard 1 hour after feeding begins.
- Tube feeding: Limit hang time to a maximum of 4 hours.

Use immediately or store unused fortified human milk in the refrigerator; use within 24 hours or according to hospital procedures for handling human milk.
After refrigeration, remix gently if needed and feed promptly.
Store unopened packets at room temperature in this protective carton; avoid extreme temperatures.

Similac Human Milk Fortifier Extensively Hydrolyzed Protein Concentrated Liquid (HMF HP CL) Mixing Chart

	Additional Cal Desired	Preterm Human Milk	Similac HMF HP CL
For Initiation	2 Cal/30 mL	50 mL	1 packet (0.9 g)
For Full Strength Feeding	4 Cal/30 mL	25 mL	1 packet (0.9 g)

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Nutrition

Preterm Human Milk

Serving size: 100 Cal (50 mL PTHM + 1 packet SHMF HP CL)

Value

Product Characteristics

Cal/30 mL
30^†

Protein (% of total energy)
N/A

Protein Source
Preterm human milk

Fat (% of total energy)
N/A

MCT oil (% of total fats)
N/A

Omega-6:Omega-3 Ratio
N/A

Fat Source
Preterm human milk

Carbohydrate (% of total energy)
N/A

Carbohydrate Source
Preterm human milk

Total Cal:g Nitrogen Ratio
N/A

Nonprotein Cal:g Nitrogen Ratio
N/A

Water (g/30 mL)
25.3

Osmolality (mOsm/kg water)
N/A

Renal Solute Load (mOsm/L)
N/A

^† The nutrient concentrations listed for preterm human milk are mean human milk levels. The range of nutrients in preterm human milk is highly variable (Meeting the Special Nutrient Needs of Low-Birth-Weight and Premature Infants in the Hospital (A8100). Columbus, Ohio: Abbott Nutrition, Abbott Laboratories, January 1998, p 56). Values for term human milk have been used for linoleic acid, biotin, choline, inositol, manganese, iodine, and selenium (American Academy of Pediatrics Committee on Nutrition: Pediatric Nutrition Handbook, 4th ed. Elk Grove Village: American Academy).

Amount per Serving

Nutrient Data

Energy, Cal
100^*

Protein, g
2.97

Volume, mL
136

Water, g
117

Fat, g
5.32

Linoleic Acid, g
0.499

Carbohydrate, g
10.04

Osmolality, mOsm/kg water
375

Potential Renal Solute Load, mOsm
26.4

Vitamins

Vitamin A, IU
966

Vitamin D, IU
89

Vitamin E, IU
3.8

Vitamin K, mg
0.0062

Vitamin C, mg
32.2

Thiamine, mg
0.144

Riboflavin, mg
0.242

Niacin, mg
2.602

Vitamin B6, mg
0.141

Folic Acid, mg
0.0213

Vitamin B12, mg
0.00038

Pantothenic Acid, mg
0.987

Biotin, mg
0.0148

Choline, mg
13.8

Inositol, mg
22.4

Minerals

Sodium, mg
43

Potassium, mg
122

Chloride, mg
100

Calcium, mg
105

Phosphorus, mg
58

Magnesium, mg
9.0

Iron, mg
0.42

Zinc, mg
1.19

Iodine, mg
0.014

Copper, mg
0.116

Manganese, mg
0.0062

Selenium, mg
0.0020

^* The nutrient concentrations listed for preterm human milk are mean human milk levels. The range of nutrients in preterm human milk is highly variable (Meeting the Special Nutrient Needs of Low-Birth-Weight and Premature Infants in the Hospital (A8100). Columbus, Ohio: Abbott Nutrition, Abbott Laboratories, January 1998, p 56). Values for term human milk have been used for linoleic acid, biotin, choline, inositol, manganese, iodine, and selenium (American Academy of Pediatrics Committee on Nutrition: Pediatric Nutrition Handbook, 4th ed. Elk Grove Village: American Academy).

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Ingredients

Preterm Human Milk

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Availability

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

LIST NUMBER

ITEM

Features

Commercially sterile liquid:
- A safer choice for preterm and low-birth-weight infants;^1,2,3
- Preferred for even distribution during mixing;³
- Heat treated for sterility (non-acidified product).
Concentrated to minimize displacement; each packet displaces 5 mL.^*
Extensively hydrolyzed protein for easy digestion and absorption.
When added to human milk, meets expert recommendations for protein^* and other nutrients for the preterm infant.^4,5
Clinically proven to support weight, length and head circumference gains in preterm babies.^6,7,8
Safe and well tolerated by preterm infants.^6,7,8
Contains an exclusive blend of DHA, lutein and natural vitamin E^†, all found in the infant brain and eyes.^9,10,11,12
Low iron content provides flexibility to add iron as needed.
Gluten-free.

PRECAUTIONS

This product is nutritionally incomplete by itself and is designed to be added to human milk.
Add only to human milk - do not add water.
Never use a microwave oven to warm fortified human milk; serious burns can result. Test temperature before feeding to avoid scalding the baby’s mouth.
Follow label instructions when using this product. Abbott has not evaluated this product to fortify human milk in a clinical trial at energy densities greater than 24 Cal/30 mL (81 Cal/100 mL). Therefore, the occasional use of a higher energy density should be done under strict medical supervision.
Additional iron may be necessary.
Tolerance to enteral feedings should be confirmed by offering small volumes of unfortified human milk.
Once enteral feeding is well established, Similac® Human Milk Fortifier Extensively Hydrolyzed Protein Concentrated Liquid can be added to human milk.
Not intended for feeding low-birth-weight infants after they reach a weight of 3600 g (approximately 8 lb) or as directed by a health care professional.
Not for parenteral use.

^* One packet mixed with 25 mL of human milk.

¹ Government of Canada. Preparing and handling powdered infant formula. Last modiﬁed on 2021-04-16. [Accessed online on 2021-05-30].

^† RRR-alpha-tocopherol, the most bioactive form of vitamin E.

² Centers for Disease Control and Prevention. Cronobacter Infection and Infants. Last reviewed on 2021-02-08. [Accessed online on 2021-07-06].

⁴ Koletzko B, et al. Nutritional Care of Preterm Infants. Scientific Basis and Practical Guidelines. World Rev Nutr Diet. Basel, Karger, 2021, vol 122 pp 191-197.

⁵ Embleton ND, et al. JPGN 2022;76:248–268.

⁶ Kim JH, et al. J Pediatr Gastroenterol Nutr. 2015;61-665-71.

⁷ Kumar N, et al. Am J Perinatol. 2017;34(14):1411-6.

⁸ Schanler RJ, et al. J Pediatr. 2018;202:31-7.

⁹ Krinsky NI, et al. Annu Rev Nutr. 2003;23:171-201.

¹⁰ Vishwanathan R, et al. JPGN. 2014;59(5):659-65.

¹¹ Kuchan MJ, et al. Br J Nutr. 2016;116(1):126-31.

¹² Kuchan MJ, et al. Curr Dev Nutr. 2018;2:nzy055

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Preparation

Directions for Use:

USE AS DIRECTED BY A HEALTH CARE PROFESSIONAL.
ADD ONLY TO HUMAN MILK. DO NOT ADD WATER.

Pour desired quantity of human milk into sterile feeding container.
Product separation is normal. Massage contents until uniform.
To open packet, tear top off completely along perforation.
Add fortifier to human milk and gently shake until mixed well.
Use or refrigerate immediately.
- Bottle feeding: Discard 1 hour after feeding begins.
- Tube feeding: Limit hang time to a maximum of 4 hours.

Use immediately or store unused fortified human milk in the refrigerator; use within 24 hours or according to hospital procedures for handling human milk.
After refrigeration, remix gently if needed and feed promptly.
Store unopened packets at room temperature in this protective carton; avoid extreme temperatures.

Similac Human Milk Fortifier Extensively Hydrolyzed Protein Concentrated Liquid (HMF HP CL) Mixing Chart

	Additional Cal Desired	Preterm Human Milk	Similac HMF HP CL
For Initiation	2 Cal/30 mL	50 mL	1 packet (0.9 g)
For Full Strength Feeding	4 Cal/30 mL	25 mL	1 packet (0.9 g)

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Nutrition

Preterm Human Milk

Serving size: 100 Cal (25 mL PTHM + 1 packets SHMF HP CL)

Value

Product Characteristics

Cal/30 mL
30^†

Protein (% of total energy)
N/A

Protein Source
Preterm human milk

Fat (% of total energy)
N/A

MCT oil (% of total fats)
N/A

Omega-6:Omega-3 Ratio
N/A

Fat Source
Preterm human milk

Carbohydrate (% of total energy)
N/A

Carbohydrate Source
Preterm human milk

Total Cal:g Nitrogen Ratio
N/A

Nonprotein Cal:g Nitrogen Ratio
N/A

Water (g/30 mL)
25.3

Osmolality (mOsm/kg water)
N/A

Renal Solute Load (mOsm/L)
N/A

^† The nutrient concentrations listed for preterm human milk are mean human milk levels. The range of nutrients in preterm human milk is highly variable (Meeting the Special Nutrient Needs of Low-Birth-Weight and Premature Infants in the Hospital (A8100). Columbus, Ohio: Abbott Nutrition, Abbott Laboratories, January 1998, p 56). Values for term human milk have been used for linoleic acid, biotin, choline, inositol, manganese, iodine, and selenium (American Academy of Pediatrics Committee on Nutrition: Pediatric Nutrition Handbook, 4th ed. Elk Grove Village: American Academy).

Amount per Serving

Nutrient Data

Energy, Cal
100^*

Protein, g
3.58

Volume, mL
126

Water, g
106

Fat, g
4.98

Linoleic Acid, g
0.464

Carbohydrate, g
10.14

Osmolality, mOsm/kg water
450

Potential Renal Solute Load, mOsm
32.0

Vitamins

Vitamin A, IU
1238

Vitamin D, IU
149

Vitamin E, IU
5.3

Vitamin K, mg
0.0103

Vitamin C, mg
43.7

Thiamine, mg
0.224

Riboflavin, mg
0.362

Niacin, mg
4.279

Vitamin B6, mg
0.226

Folic Acid, mg
0.0329

Vitamin B12, mg
0.00060

Pantothenic Acid, mg
1.494

Biotin, mg
0.0248

Choline, mg
13.7

Inositol, mg
22.7

Minerals

Sodium, mg
47

Potassium, mg
148

Chloride, mg
113

Calcium, mg
152

Phosphorus, mg
85

Magnesium, mg
12.1

Iron, mg
0.59

Zinc, mg
1.66

Iodine, mg
0.013

Copper, mg
0.131

Manganese, mg
0.0099

Selenium, mg
0.0020

^* The nutrient concentrations listed for preterm human milk are mean human milk levels. The range of nutrients in preterm human milk is highly variable (Meeting the Special Nutrient Needs of Low-Birth-Weight and Premature Infants in the Hospital (A8100). Columbus, Ohio: Abbott Nutrition, Abbott Laboratories, January 1998, p 56). Values for term human milk have been used for linoleic acid, biotin, choline, inositol, manganese, iodine, and selenium (American Academy of Pediatrics Committee on Nutrition: Pediatric Nutrition Handbook, 4th ed. Elk Grove Village: American Academy).

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Ingredients

Preterm Human Milk

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Availability

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

LIST NUMBER

ITEM

Features

Commercially sterile liquid:
- A safer choice for preterm and low-birth-weight infants;^1,2,3
- Preferred for even distribution during mixing;³
- Heat treated for sterility (non-acidified product).
Concentrated to minimize displacement; each packet displaces 5 mL.^*
Extensively hydrolyzed protein for easy digestion and absorption.
When added to human milk, meets expert recommendations for protein^* and other nutrients for the preterm infant.^4,5
Clinically proven to support weight, length and head circumference gains in preterm babies.^6,7,8
Safe and well tolerated by preterm infants.^6,7,8
Contains an exclusive blend of DHA, lutein and natural vitamin E^†, all found in the infant brain and eyes.^9,10,11,12
Low iron content provides flexibility to add iron as needed.
Gluten-free.

PRECAUTIONS

This product is nutritionally incomplete by itself and is designed to be added to human milk.
Add only to human milk - do not add water.
Never use a microwave oven to warm fortified human milk; serious burns can result. Test temperature before feeding to avoid scalding the baby’s mouth.
Follow label instructions when using this product. Abbott has not evaluated this product to fortify human milk in a clinical trial at energy densities greater than 24 Cal/30 mL (81 Cal/100 mL). Therefore, the occasional use of a higher energy density should be done under strict medical supervision.
Additional iron may be necessary.
Tolerance to enteral feedings should be confirmed by offering small volumes of unfortified human milk.
Once enteral feeding is well established, Similac® Human Milk Fortifier Extensively Hydrolyzed Protein Concentrated Liquid can be added to human milk.
Not intended for feeding low-birth-weight infants after they reach a weight of 3600 g (approximately 8 lb) or as directed by a health care professional.
Not for parenteral use.

^* One packet mixed with 25 mL of human milk.

¹ Government of Canada. Preparing and handling powdered infant formula. Last modiﬁed on 2021-04-16. [Accessed online on 2021-05-30].

^† RRR-alpha-tocopherol, the most bioactive form of vitamin E.

² Centers for Disease Control and Prevention. Cronobacter Infection and Infants. Last reviewed on 2021-02-08. [Accessed online on 2021-07-06].

⁴ Koletzko B, et al. Nutritional Care of Preterm Infants. Scientific Basis and Practical Guidelines. World Rev Nutr Diet. Basel, Karger, 2021, vol 122 pp 191-197.

⁵ Embleton ND, et al. JPGN 2022;76:248–268.

⁶ Kim JH, et al. J Pediatr Gastroenterol Nutr. 2015;61-665-71.

⁷ Kumar N, et al. Am J Perinatol. 2017;34(14):1411-6.

⁸ Schanler RJ, et al. J Pediatr. 2018;202:31-7.

⁹ Krinsky NI, et al. Annu Rev Nutr. 2003;23:171-201.

¹⁰ Vishwanathan R, et al. JPGN. 2014;59(5):659-65.

¹¹ Kuchan MJ, et al. Br J Nutr. 2016;116(1):126-31.

¹² Kuchan MJ, et al. Curr Dev Nutr. 2018;2:nzy055

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Preparation

Directions for Use:

USE AS DIRECTED BY A HEALTH CARE PROFESSIONAL.
ADD ONLY TO HUMAN MILK. DO NOT ADD WATER.

Pour desired quantity of human milk into sterile feeding container.
Product separation is normal. Massage contents until uniform.
To open packet, tear top off completely along perforation.
Add fortifier to human milk and gently shake until mixed well.
Use or refrigerate immediately.
- Bottle feeding: Discard 1 hour after feeding begins.
- Tube feeding: Limit hang time to a maximum of 4 hours.

Use immediately or store unused fortified human milk in the refrigerator; use within 24 hours or according to hospital procedures for handling human milk.
After refrigeration, remix gently if needed and feed promptly.
Store unopened packets at room temperature in this protective carton; avoid extreme temperatures.

Similac Human Milk Fortifier Extensively Hydrolyzed Protein Concentrated Liquid (HMF HP CL) Mixing Chart

	Additional Cal Desired	Preterm Human Milk	Similac HMF HP CL
For Initiation	2 Cal/30 mL	50 mL	1 packet (0.9 g)
For Full Strength Feeding	4 Cal/30 mL	25 mL	1 packet (0.9 g)

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Nutrition

Preterm Human Milk

Serving size: 100 mL

Value

Product Characteristics

Cal/30 mL
30^†

Protein (% of total energy)
N/A

Protein Source
Preterm human milk

Fat (% of total energy)
N/A

MCT oil (% of total fats)
N/A

Omega-6:Omega-3 Ratio
N/A

Fat Source
Preterm human milk

Carbohydrate (% of total energy)
N/A

Carbohydrate Source
Preterm human milk

Total Cal:g Nitrogen Ratio
N/A

Nonprotein Cal:g Nitrogen Ratio
N/A

Water (g/30 mL)
25.3

Osmolality (mOsm/kg water)
N/A

Renal Solute Load (mOsm/L)
N/A

^† The nutrient concentrations listed for preterm human milk are mean human milk levels. The range of nutrients in preterm human milk is highly variable (Meeting the Special Nutrient Needs of Low-Birth-Weight and Premature Infants in the Hospital (A8100). Columbus, Ohio: Abbott Nutrition, Abbott Laboratories, January 1998, p 56). Values for term human milk have been used for linoleic acid, biotin, choline, inositol, manganese, iodine, and selenium (American Academy of Pediatrics Committee on Nutrition: Pediatric Nutrition Handbook, 4th ed. Elk Grove Village: American Academy).

Amount per Serving

Nutrient Data

Energy, Cal
67^*

Protein, g
1.41

Volume, mL
100

Water, g
88

Fat, g
3.89

Linoleic Acid, g
0.369

Carbohydrate, g
6.64

Osmolality, mOsm/kg water
290

Potential Renal Solute Load, mOsm
12.6

Vitamins

Vitamin A, IU
390

Vitamin D, IU
2

Vitamin E, IU
1.1

Vitamin K, mg
0.0002

Vitamin C, mg
10.7

Thiamine, mg
0.021

Riboflavin, mg
0.048

Niacin, mg
0.150

Vitamin B6, mg
0.015

Folic Acid, mg
0.0033

Vitamin B12, mg
0.00005

Pantothenic Acid, mg
0.181

Biotin, mg
0.0004

Choline, mg
9.4

Inositol, mg
14.8

Minerals

Sodium, mg
25

Potassium, mg
57

Chloride, mg
55

Calcium, mg
25

Phosphorus, mg
13

Magnesium, mg
3.1

Iron, mg
0.12

Zinc, mg
0.34

Iodine, mg
0.011

Copper, mg
0.064

Manganese, mg
0.0006

Selenium, mg
0.001

^* The nutrient concentrations listed for preterm human milk are mean human milk levels. The range of nutrients in preterm human milk is highly variable (Meeting the Special Nutrient Needs of Low-Birth-Weight and Premature Infants in the Hospital (A8100). Columbus, Ohio: Abbott Nutrition, Abbott Laboratories, January 1998, p 56). Values for term human milk have been used for linoleic acid, biotin, choline, inositol, manganese, iodine, and selenium (American Academy of Pediatrics Committee on Nutrition: Pediatric Nutrition Handbook, 4th ed. Elk Grove Village: American Academy).

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Ingredients

Preterm Human Milk

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Availability

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

LIST NUMBER

ITEM

Features

Commercially sterile liquid:
- A safer choice for preterm and low-birth-weight infants;^1,2,3
- Preferred for even distribution during mixing;³
- Heat treated for sterility (non-acidified product).
Concentrated to minimize displacement; each packet displaces 5 mL.^*
Extensively hydrolyzed protein for easy digestion and absorption.
When added to human milk, meets expert recommendations for protein^* and other nutrients for the preterm infant.^4,5
Clinically proven to support weight, length and head circumference gains in preterm babies.^6,7,8
Safe and well tolerated by preterm infants.^6,7,8
Contains an exclusive blend of DHA, lutein and natural vitamin E^†, all found in the infant brain and eyes.^9,10,11,12
Low iron content provides flexibility to add iron as needed.
Gluten-free.

PRECAUTIONS

This product is nutritionally incomplete by itself and is designed to be added to human milk.
Add only to human milk - do not add water.
Never use a microwave oven to warm fortified human milk; serious burns can result. Test temperature before feeding to avoid scalding the baby’s mouth.
Follow label instructions when using this product. Abbott has not evaluated this product to fortify human milk in a clinical trial at energy densities greater than 24 Cal/30 mL (81 Cal/100 mL). Therefore, the occasional use of a higher energy density should be done under strict medical supervision.
Additional iron may be necessary.
Tolerance to enteral feedings should be confirmed by offering small volumes of unfortified human milk.
Once enteral feeding is well established, Similac® Human Milk Fortifier Extensively Hydrolyzed Protein Concentrated Liquid can be added to human milk.
Not intended for feeding low-birth-weight infants after they reach a weight of 3600 g (approximately 8 lb) or as directed by a health care professional.
Not for parenteral use.

^* One packet mixed with 25 mL of human milk.

¹ Government of Canada. Preparing and handling powdered infant formula. Last modiﬁed on 2021-04-16. [Accessed online on 2021-05-30].

^† RRR-alpha-tocopherol, the most bioactive form of vitamin E.

² Centers for Disease Control and Prevention. Cronobacter Infection and Infants. Last reviewed on 2021-02-08. [Accessed online on 2021-07-06].

⁴ Koletzko B, et al. Nutritional Care of Preterm Infants. Scientific Basis and Practical Guidelines. World Rev Nutr Diet. Basel, Karger, 2021, vol 122 pp 191-197.

⁵ Embleton ND, et al. JPGN 2022;76:248–268.

⁶ Kim JH, et al. J Pediatr Gastroenterol Nutr. 2015;61-665-71.

⁷ Kumar N, et al. Am J Perinatol. 2017;34(14):1411-6.

⁸ Schanler RJ, et al. J Pediatr. 2018;202:31-7.

⁹ Krinsky NI, et al. Annu Rev Nutr. 2003;23:171-201.

¹⁰ Vishwanathan R, et al. JPGN. 2014;59(5):659-65.

¹¹ Kuchan MJ, et al. Br J Nutr. 2016;116(1):126-31.

¹² Kuchan MJ, et al. Curr Dev Nutr. 2018;2:nzy055

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Preparation

Directions for Use:

USE AS DIRECTED BY A HEALTH CARE PROFESSIONAL.
ADD ONLY TO HUMAN MILK. DO NOT ADD WATER.

Pour desired quantity of human milk into sterile feeding container.
Product separation is normal. Massage contents until uniform.
To open packet, tear top off completely along perforation.
Add fortifier to human milk and gently shake until mixed well.
Use or refrigerate immediately.
- Bottle feeding: Discard 1 hour after feeding begins.
- Tube feeding: Limit hang time to a maximum of 4 hours.

Use immediately or store unused fortified human milk in the refrigerator; use within 24 hours or according to hospital procedures for handling human milk.
After refrigeration, remix gently if needed and feed promptly.
Store unopened packets at room temperature in this protective carton; avoid extreme temperatures.

Similac Human Milk Fortifier Extensively Hydrolyzed Protein Concentrated Liquid (HMF HP CL) Mixing Chart

	Additional Cal Desired	Preterm Human Milk	Similac HMF HP CL
For Initiation	2 Cal/30 mL	50 mL	1 packet (0.9 g)
For Full Strength Feeding	4 Cal/30 mL	25 mL	1 packet (0.9 g)

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Nutrition

Preterm Human Milk

Serving size: 100 mL (50 mL PTHM + 1 packet SHMF HP CL)

Value

Product Characteristics

Cal/30 mL
30^†

Protein (% of total energy)
N/A

Protein Source
Preterm human milk

Fat (% of total energy)
N/A

MCT oil (% of total fats)
N/A

Omega-6:Omega-3 Ratio
N/A

Fat Source
Preterm human milk

Carbohydrate (% of total energy)
N/A

Carbohydrate Source
Preterm human milk

Total Cal:g Nitrogen Ratio
N/A

Nonprotein Cal:g Nitrogen Ratio
N/A

Water (g/30 mL)
25.3

Osmolality (mOsm/kg water)
N/A

Renal Solute Load (mOsm/L)
N/A

^† The nutrient concentrations listed for preterm human milk are mean human milk levels. The range of nutrients in preterm human milk is highly variable (Meeting the Special Nutrient Needs of Low-Birth-Weight and Premature Infants in the Hospital (A8100). Columbus, Ohio: Abbott Nutrition, Abbott Laboratories, January 1998, p 56). Values for term human milk have been used for linoleic acid, biotin, choline, inositol, manganese, iodine, and selenium (American Academy of Pediatrics Committee on Nutrition: Pediatric Nutrition Handbook, 4th ed. Elk Grove Village: American Academy).

Amount per Serving

Nutrient Data

Energy, Cal^*
74^*

Protein, g
2.19

Volume, mL
100

Water, g
86

Fat, g
3.92

Linoleic Acid, g
0.368

Carbohydrate, g
7.40

Osmolality, mOsm/kg water
375

Potential Renal Solute Load, mOsm
19.5

Vitamins

Vitamin A, IU
713

Vitamin D, IU
65

Vitamin E, IU
2.8

Vitamin K, mg
0.0045

Vitamin C, mg
23.8

Thiamine, mg
0.106

Riboflavin, mg
0.178

Niacin, mg
1.918

Vitamin B6, mg
0.104

Folic Acid, mg
0.0157

Vitamin B12, mg
0.00028

Pantothenic Acid, mg
0.728

Biotin, mg
0.0109

Choline, mg
10.2

Inositol, mg
16.5

Minerals

Sodium, mg
32

Potassium, mg
90

Chloride, mg
74

Calcium, mg
77

Phosphorus, mg
43

Magnesium, mg
6.6

Iron, mg
0.31

Zinc, mg
0.87

Iodine, mg
0.010

Copper, mg
0.086

Manganese, mg
0.0045

Selenium, mg
0.002

^* The nutrient concentrations listed for preterm human milk are mean human milk levels. The range of nutrients in preterm human milk is highly variable (Meeting the Special Nutrient Needs of Low-Birth-Weight and Premature Infants in the Hospital (A8100). Columbus, Ohio: Abbott Nutrition, Abbott Laboratories, January 1998, p 56). Values for term human milk have been used for linoleic acid, biotin, choline, inositol, manganese, iodine, and selenium (American Academy of Pediatrics Committee on Nutrition: Pediatric Nutrition Handbook, 4th ed. Elk Grove Village: American Academy).

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Ingredients

Preterm Human Milk

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Availability

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

LIST NUMBER

ITEM

Features

Commercially sterile liquid:
- A safer choice for preterm and low-birth-weight infants;^1,2,3
- Preferred for even distribution during mixing;³
- Heat treated for sterility (non-acidified product).
Concentrated to minimize displacement; each packet displaces 5 mL.^*
Extensively hydrolyzed protein for easy digestion and absorption.
When added to human milk, meets expert recommendations for protein^* and other nutrients for the preterm infant.^4,5
Clinically proven to support weight, length and head circumference gains in preterm babies.^6,7,8
Safe and well tolerated by preterm infants.^6,7,8
Contains an exclusive blend of DHA, lutein and natural vitamin E^†, all found in the infant brain and eyes.^9,10,11,12
Low iron content provides flexibility to add iron as needed.
Gluten-free.

PRECAUTIONS

This product is nutritionally incomplete by itself and is designed to be added to human milk.
Add only to human milk - do not add water.
Never use a microwave oven to warm fortified human milk; serious burns can result. Test temperature before feeding to avoid scalding the baby’s mouth.
Follow label instructions when using this product. Abbott has not evaluated this product to fortify human milk in a clinical trial at energy densities greater than 24 Cal/30 mL (81 Cal/100 mL). Therefore, the occasional use of a higher energy density should be done under strict medical supervision.
Additional iron may be necessary.
Tolerance to enteral feedings should be confirmed by offering small volumes of unfortified human milk.
Once enteral feeding is well established, Similac® Human Milk Fortifier Extensively Hydrolyzed Protein Concentrated Liquid can be added to human milk.
Not intended for feeding low-birth-weight infants after they reach a weight of 3600 g (approximately 8 lb) or as directed by a health care professional.
Not for parenteral use.

^* One packet mixed with 25 mL of human milk.

¹ Government of Canada. Preparing and handling powdered infant formula. Last modiﬁed on 2021-04-16. [Accessed online on 2021-05-30].

^† RRR-alpha-tocopherol, the most bioactive form of vitamin E.

² Centers for Disease Control and Prevention. Cronobacter Infection and Infants. Last reviewed on 2021-02-08. [Accessed online on 2021-07-06].

⁴ Koletzko B, et al. Nutritional Care of Preterm Infants. Scientific Basis and Practical Guidelines. World Rev Nutr Diet. Basel, Karger, 2021, vol 122 pp 191-197.

⁵ Embleton ND, et al. JPGN 2022;76:248–268.

⁶ Kim JH, et al. J Pediatr Gastroenterol Nutr. 2015;61-665-71.

⁷ Kumar N, et al. Am J Perinatol. 2017;34(14):1411-6.

⁸ Schanler RJ, et al. J Pediatr. 2018;202:31-7.

⁹ Krinsky NI, et al. Annu Rev Nutr. 2003;23:171-201.

¹⁰ Vishwanathan R, et al. JPGN. 2014;59(5):659-65.

¹¹ Kuchan MJ, et al. Br J Nutr. 2016;116(1):126-31.

¹² Kuchan MJ, et al. Curr Dev Nutr. 2018;2:nzy055

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Preparation

Directions for Use:

USE AS DIRECTED BY A HEALTH CARE PROFESSIONAL.
ADD ONLY TO HUMAN MILK. DO NOT ADD WATER.

Pour desired quantity of human milk into sterile feeding container.
Product separation is normal. Massage contents until uniform.
To open packet, tear top off completely along perforation.
Add fortifier to human milk and gently shake until mixed well.
Use or refrigerate immediately.
- Bottle feeding: Discard 1 hour after feeding begins.
- Tube feeding: Limit hang time to a maximum of 4 hours.

Use immediately or store unused fortified human milk in the refrigerator; use within 24 hours or according to hospital procedures for handling human milk.
After refrigeration, remix gently if needed and feed promptly.
Store unopened packets at room temperature in this protective carton; avoid extreme temperatures.

Similac Human Milk Fortifier Extensively Hydrolyzed Protein Concentrated Liquid (HMF HP CL) Mixing Chart

	Additional Cal Desired	Preterm Human Milk	Similac HMF HP CL
For Initiation	2 Cal/30 mL	50 mL	1 packet (0.9 g)
For Full Strength Feeding	4 Cal/30 mL	25 mL	1 packet (0.9 g)

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Nutrition

Preterm Human Milk

Serving size: 100 mL (25 mL PTHM + 1 packet SHMF HP CL)

Value

Product Characteristics

Cal/30 mL
30^†

Protein (% of total energy)
N/A

Protein Source
Preterm human milk

Fat (% of total energy)
N/A

MCT oil (% of total fats)
N/A

Omega-6:Omega-3 Ratio
N/A

Fat Source
Preterm human milk

Carbohydrate (% of total energy)
N/A

Carbohydrate Source
Preterm human milk

Total Cal:g Nitrogen Ratio
N/A

Nonprotein Cal:g Nitrogen Ratio
N/A

Water (g/30 mL)
25.3

Osmolality (mOsm/kg water)
N/A

Renal Solute Load (mOsm/L)
N/A

^† The nutrient concentrations listed for preterm human milk are mean human milk levels. The range of nutrients in preterm human milk is highly variable (Meeting the Special Nutrient Needs of Low-Birth-Weight and Premature Infants in the Hospital (A8100). Columbus, Ohio: Abbott Nutrition, Abbott Laboratories, January 1998, p 56). Values for term human milk have been used for linoleic acid, biotin, choline, inositol, manganese, iodine, and selenium (American Academy of Pediatrics Committee on Nutrition: Pediatric Nutrition Handbook, 4th ed. Elk Grove Village: American Academy).

Amount per Serving

Nutrient Data

Energy, Cal
79^*

Protein, g
2.84

Volume, mL
100

Water, g
84

Fat, g
3.94

Linoleic Acid, g
0.368

Carbohydrate, g
8.04

Osmolality, mOsm/kg water
450

Potential Renal Solute Load, mOsm
25.7

Vitamins

Vitamin A, IU
982

Vitamin D, IU
118

Vitamin E, IU
4.2

Vitamin K, mg
0.0082

Vitamin C, mg
34.6

Thiamine, mg
0.177

Riboflavin, mg
0.287

Niacin, mg
3.392

Vitamin B6, mg
0.179

Folic Acid, mg
0.0261

Vitamin B12, mg
0.00047

Pantothenic Acid, mg
1.184

Biotin, mg
0.0197

Choline, mg
10.8

Inositol, mg
18.0

Minerals

Sodium, mg
37

Potassium, mg
118

Chloride, mg
89

Calcium, mg
121

Phosphorus, mg
67

Magnesium, mg
9.6

Iron, mg
0.47

Zinc, mg
1.32

Iodine, mg
0.010

Copper, mg
0.104

Manganese, mg
0.0078

Selenium, mg
0.002

^* The nutrient concentrations listed for preterm human milk are mean human milk levels. The range of nutrients in preterm human milk is highly variable (Meeting the Special Nutrient Needs of Low-Birth-Weight and Premature Infants in the Hospital (A8100). Columbus, Ohio: Abbott Nutrition, Abbott Laboratories, January 1998, p 56). Values for term human milk have been used for linoleic acid, biotin, choline, inositol, manganese, iodine, and selenium (American Academy of Pediatrics Committee on Nutrition: Pediatric Nutrition Handbook, 4th ed. Elk Grove Village: American Academy).

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Ingredients

Preterm Human Milk

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

SIMILAC® HUMAN MILK FORTIFIER EXTENSIVELY HYDROLYZED PROTEIN CONCENTRATED LIQUID

For preterm or low-birth-weight infants

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