Similac Pro-Advance® Step 1 Ready to Use

SIMILAC PRO-ADVANCE^® STEP 1 READY TO USE

with 2'-FL oligosaccharide / DHA- and ARA-fortified

For use as a breast milk substitute in infants who are not exclusively breastfed. For oral or tube feeding use.

Download Product Guide (PDF 117 KB)

Availability

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

LIST NUMBER

ITEM

6818413

Similac Pro-Advance® Step 1, Ready to Use; 59-mL plastic bottles; 24/case

Features

Our most advanced formula with 2’-FL.^*
2'-FL^* is structurally identical to 2'-FL human milk oligosaccharide (HMO),¹ the most abundant HMO found in the breast milk of most mothers.²
Addition of 2'-FL^* to infant formula may help support the development and regulation of the formula-fed baby's immune response to be closer to that of breastfed infants.^3,†
DHA, an Omega-3 fatty acid that supports the normal physical development of the brain and eyes.⁴
Lutein, an antioxidant found in breast milk and concentrated in the infant brain and eyes.^5,6,7 Recent studies show that lutein may have a role in visual and cognitive development.⁸
Vitamin E, a dietary antioxidant that protects fats in body tissues from oxidation.⁹ Similac Pro-Advance® uses natural vitamin E,^‡ the most abundant form found in breast milk and in the infant brain.^10,11
Non-GMO.^§
Easy to digest.^¶
Gluten-free.
Kosher.
Halal.

PRECAUTIONS

Not for parenteral use.

^* Not derived from human milk.

¹ Weichert S et al. Nutr Res 2013;33(10):831-8.

^† Breast milk is best for babies, contains many immune factors not available in infant formula, and its use is recommended for as long as possible during infancy.

² Castanys-Muñoz E et al. Nutr Rev 2013;71(12):773-89.

^‡ RRR-alpha-tocopherol, the most bioactive form of vitamin E.

³ Goehring KC, et al. J Nutr. 2016;146(12):2559-2566.

^§ Ingredients not genetically engineered.

⁴ Canadian Food Inspection Agency: Health Claims – Nutrient Function Claims. Last modiﬁed on 2019-10-31. [Accessed online on 2023-11-14]

^¶ Similar to other infant formulas.

⁵ Zimmer JP, et al. Clin Ophtalmol. 2007;1:25-35.

⁶ Krinsky NI, et al. Annu Rev Nutr. 2003;23:171-201.

⁷ Vishwanathan R, et al. JPGN. 2014;59(5):659-65.

⁸ Johnson EJ. Nutr Rev. 2014;72(9):605-12.

⁹ Kuchan MJ, et al. Curr Dev Nutr. 2018;2:nzy055

¹⁰ Kuchan MJ, et al. Br J Nutr. 2016;116(1):126-31.

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Preparation

Directions for Use:

Your baby's health depends on carefully following these directions. Proper hygiene, preparation and storage are important when using infant formula. Failure to follow these directions could result in severe harm. Use as directed by your health care professional.

Do not add water

Do not use if breakaway ring is missing or broken.

Once feeding begins, use with 1 hour or discard.

WARNING: Do not use the Similac® bottle to warm formula. Never use a microwave oven to warm formula; serious burns can result. Test temperature before feeding to avoid scalding the baby’s mouth.

Wash hands thoroughly with soap and water.
Place washed cups or bottles (if needed), nipples, rings, caps and all preparation equipment in boiling water and keep at a rolling boil for 2 minutes.
SHAKE BOTTLE WELL and twist off cap.
If using a Similac® bottle: Attach sterilized nipple. If using a different feeding container: Pour formula into cups or bottles. If there is formula remaining in the Similac® bottle, refrigerate and use within 48 hours.

Storage

Store unopened bottles under normal room temperature conditions; avoid extreme temperatures. Cover opened or prepared bottles/cups, refrigerate and use within 48 hours. Do not reuse the Similac® bottle. Once feeding begins, use within 1 hour or discard.

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Nutrition

Unflavored Ready to Use

Similac Pro-Advance® Step 1, Ready to Use; 59-mL plastic bottles; 24/case

Serving size: 100 mL

Value

Product Characteristics

Caloric Density (Cal/mL)
0.68

Protein (% of total energy)
8.3

Protein Source
Dry or evaporated skim milk, whey protein concentrate

Fat (% of total energy)
49.3

Omega-6:Omega-3 Ratio
8.12:1

MCT oil (% of total fats)
0

Fat Source
High oleic safflower oil, soy oil, coconut oil, M. alpina oil, Schizochytrium sp. oil, soy lecithin

Carbohydrate (% of total energy)
42.4

Carbohydrate Source
Lactose, fructooligosaccharides, 2’-fucosyllactose

Total Cal:g Nitrogen Ratio
304:1

Nonprotein Cal:g Nitrogen Ratio
277:1

Water (g/L)
904

Osmolality (mOsm/kg water)
306

Renal Solute Load (mOsm/L)
127

Recommended Tube Size for Gravity/Pump Feeding (Fr)
N/A

Amount per Serving

Nutrient Data

ENERGY, Cal (kJ)
68 (280)

Protein, g
1.4

Taurine, mg
4.1

Carnitine, mg
0.82

Tryptophan, mg
22

Fat, g
3.7

Linoleic Acid, g
0.65

Linolenic Acid, g
0.063

Arachidonic Acid (ARA), g
0.017

Docosahexaenoic Acid (DHA), g
0.011

Carbohydrate, g
7.3

Fibre, g
0.18

2'-fucosyllactose (2'-FL), mg
20

Nucleotides, mg
7.2

Vitamins

Inositol, mg
3.8

Lutein, mg
0.0053

Vitamin A, IU
203

Vitamin D, IU
35

Vitamin E, IU
2.5

Vitamin K, mg
0.0083

Vitamin C, mg
9

Thiamine, mg
0.064

Riboflavin, mg
0.11

Niacin, mg
0.45

Vitamin B6, mg
0.054

Folic Acid, mg
0.0095

Vitamin B12, mg
0.00023

Pantothenic Acid, mg
0.4

Biotin, mg
0.0025

Choline, mg
9.8

Minerals

Sodium, mg
18

Potassium, mg
79

Chloride, mg
40

Calcium, mg
53

Phosphorus, mg
26

Magnesium, mg
4.1

Iron, mg
1.1

Zinc, mg
0.45

Iodine, mg
0.0085

Copper, mg
0.047

Manganese, mg
0.004

Selenium, mg
0.0008

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Ingredients

Unflavored Ready to Use

Similac Pro-Advance® Step 1, Ready to Use; 59-mL plastic bottles; 24/case

Water, Lactose, Dry or Evaporated Skim Milk, High Oleic Safflower Oil, Soy Oil, Coconut Oil, Whey Protein Concentrate, Fructooligosaccharides, M. Alpina Oil (A Source Of ARA), Schizochytrium Sp. Oil (A Source of DHA), Monoglycerides, Soy Lecithin, 2'-Fucosyllactose (2'-FL), Carrageenan, Taurine, M-Inositol, Cytidine 5'-Monophosphate, L-Tryptophan, Disodium Guanosine 5'-Monophosphate, Disodium Uridine 5'-Monophosphate, Adenosine 5'-Monophosphate, L-Carnitine, Lutein, MINERALS (Potassium Citrate, Calcium Carbonate, Sodium Citrate, Potassium Chloride, Sodium Chloride, Potassium Phosphate Dibasic, Magnesium Chloride, Ferrous Sulphate, Potassium Hydroxide, Zinc Sulphate, Magnesium Sulphate, Copper Sulphate, Manganese Sulphate, Potassium Iodide), VITAMINS (Ascorbic Acid, Choline Bitartrate, Choline Chloride, D-Alpha-Tocopheryl Acetate, Niacinamide, Calcium D-Pantothenate, Vitamin A Palmitate, Thiamine Chloride Hydrochloride, Riboflavin, Pyridoxine Hydrochloride, Folic Acid, Phylloquinone, Beta-Carotene, D-Biotin, Vitamin D3, and Cyanocobalamin).

Contains: Milk, Soy.

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Availability

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

LIST NUMBER

ITEM

6818413

Similac Pro-Advance® Step 1, Ready to Use; 59-mL plastic bottles; 24/case

Features

Our most advanced formula with 2’-FL.^*
2'-FL^* is structurally identical to 2'-FL human milk oligosaccharide (HMO),¹ the most abundant HMO found in the breast milk of most mothers.²
Addition of 2'-FL^* to infant formula may help support the development and regulation of the formula-fed baby's immune response to be closer to that of breastfed infants.^3,†
DHA, the most abundant Omega-3 fatty acid in brain and eyes.⁴
Lutein, an antioxidant found in breast milk and concentrated in the infant brain and eyes.^5,6,7 Recent studies show that lutein may have a role in visual and cognitive development.⁸
Vitamin E, a dietary antioxidant that protects fats in body tissues from oxidation.⁹ Similac Pro-Advance® uses natural vitamin E,^‡ the most abundant form found in breast milk and in the infant brain.^10,11
Non-GMO.^§
Easy to digest.^¶
Gluten-free.
Kosher.
Halal.

PRECAUTIONS

Not for parenteral use.

^* Not derived from human milk.

¹ Weichert S et al. Nutr Res 2013;33(10):831-8.

^† Breast milk is best for babies, contains many immune factors not available in infant formula, and its use is recommended for as long as possible during infancy.

² Castanys-Muñoz E et al. Nutr Rev 2013;71(12):773-89.

^‡ RRR-alpha-tocopherol, the most bioactive form of vitamin E.

³ Goehring KC, et al. J Nutr. 2016;146(12):2559-2566.

^§ Ingredients not genetically engineered.

⁴ Canadian Food Inspection Agency: Health Claims – Nutrient Function Claims. Last modiﬁed on 2019-10-31. [Accessed online on 2023-11-14]

^¶ Similar to other infant formulas.

⁵ Zimmer JP, et al. Clin Ophtalmol. 2007;1:25-35.

⁶ Krinsky NI, et al. Annu Rev Nutr. 2003;23:171-201.

⁷ Vishwanathan R, et al. JPGN. 2014;59(5):659-65.

⁸ Johnson EJ. Nutr Rev. 2014;72(9):605-12.

⁹ Kuchan MJ, et al. Curr Dev Nutr. 2018;2:nzy055

¹⁰ Kuchan MJ, et al. Br J Nutr. 2016;116(1):126-31.

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Preparation

Directions for Use:

Do not add water

Do not use if breakaway ring is missing or broken.

Once feeding begins, use with 1 hour or discard.

WARNING: Do not use the Similac® bottle to warm formula. Never use a microwave oven to warm formula; serious burns can result. Test temperature before feeding to avoid scalding the baby’s mouth.

Wash hands thoroughly with soap and water.
Place washed cups or bottles (if needed), nipples, rings, caps and all preparation equipment in boiling water and keep at a rolling boil for 2 minutes.
SHAKE BOTTLE WELL and twist off cap.
If using a Similac® bottle: Attach sterilized nipple. If using a different feeding container: Pour formula into cups or bottles. If there is formula remaining in the Similac® bottle, refrigerate and use within 48 hours.

Storage

Store unopened bottles under normal room temperature conditions; avoid extreme temperatures. Cover opened or prepared bottles/cups, refrigerate and use within 48 hours. Do not reuse the Similac® bottle. Once feeding begins, use within 1 hour or discard.

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Nutrition

Unflavored Ready to Use

Similac Pro-Advance® Step 1, Ready to Use; 59-mL plastic bottles; 24/case

Serving size: 100 Cal

Value

Product Characteristics

Caloric Density (Cal/mL)
0.68

Protein (% of total energy)
8.3

Protein Source
Dry or evaporated skim milk, whey protein concentrate

Fat (% of total energy)
49.3

Omega-6:Omega-3 Ratio
8.12:1

MCT oil (% of total fats)
0

Fat Source
High oleic safflower oil, soy oil, coconut oil, M. alpina oil, Schizochytrium sp. oil, soy lecithin

Carbohydrate (% of total energy)
42.4

Carbohydrate Source
Lactose, fructooligosaccharides, 2’-fucosyllactose

Total Cal:g Nitrogen Ratio
304:1

Nonprotein Cal:g Nitrogen Ratio
277:1

Water (g/L)
904

Osmolality (mOsm/kg water)
306

Renal Solute Load (mOsm/L)
127

Recommended Tube Size for Gravity/Pump Feeding (Fr)
N/A

Amount per Serving

Nutrient Data

ENERGY, Cal (kJ)
100 (419)

Protein, g
2.07

Taurine, mg
6.07

Carnitine, mg
1.2

Tryptophan, mg
33.1

Fat, g
5.49

Linoleic Acid, g
0.966

Linolenic Acid, g
0.093

Arachidonic Acid (ARA), g
0.025

Docosahexaenoic Acid (DHA), g
0.016

Carbohydrate, g
10.8

Fibre, g
0.27

2'-fucosyllactose (2'-FL), mg
30

Nucleotides, mg
10.7

Vitamins

Inositol, mg
5.6

Lutein, mg
0.0078

Vitamin A, IU
300

Vitamin D, IU
51.8

Vitamin E, IU
3.7

Vitamin K, mg
0.0123

Vitamin C, mg
13.3

Thiamine, mg
0.0947

Riboflavin, mg
0.163

Niacin, mg
0.666

Vitamin B6, mg
0.0799

Folic Acid, mg
0.0141

Vitamin B12, mg
0.00034

Pantothenic Acid, mg
0.59

Biotin, mg
0.0037

Choline, mg
14.5

Minerals

Sodium, mg
26.6

Potassium, mg
117

Chloride, mg
59.2

Calcium, mg
78.4

Phosphorus, mg
38.5

Magnesium, mg
6.1

Iron, mg
1.63

Zinc, mg
0.67

Iodine, mg
0.0126

Copper, mg
0.0695

Manganese, mg
0.0059

Selenium, mg
0.00118

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Ingredients

Unflavored Ready to Use

Similac Pro-Advance® Step 1, Ready to Use; 59-mL plastic bottles; 24/case

Lactose, Dry or Evaporated Skim Milk, High Oleic Safflower Oil, Whey Protein Concentrate, Soy Oil, Coconut Oil, Fructooligosaccharides, Whey Protein Hydrolysate, M. Alpina Oil (A Source Of ARA), 2'-Fucosyllactose (2'-FL), Schizochytrium Sp. Oil (A Source of DHA), Soy Lecithin, L-Tryptophan, Taurine, M-Inositol, Cytidine 5'-Monophosphate, Ascorbyl Palmitate, Disodium Guanosine 5'-Monophosphate, Disodium Uridine 5'-Monophosphate, Adenosine 5'-Monophosphate, Mixed Tocopherols, L-Carnitine, Lutein, MINERALS (Calcium Carbonate, Potassium Citrate, Potassium Hydroxide, Magnesium Chloride, Sodium Chloride, Ferrous Sulphate, Tricalcium Phosphate, Zinc Sulphate, Copper Sulphate, Manganese Sulphate, Potassium Iodide, Sodium Selenite), VITAMINS (Ascorbic Acid, Choline Bitartrate, D-Alpha-Tocopheryl Acetate, Niacinamide, Calcium D-Pantothenate, Vitamin A Palmitate, Thiamine Chloride Hydrochloride, Riboflavin, Pyridoxine Hydrochloride, Folic Acid, Beta-Carotene, Phylloquinone, Vitamin D3, D-Biotin, and Cyanocobalamin).

Contains: Milk, Soy.

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Availability

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

LIST NUMBER

ITEM

6726713

Similac Pro-Advance® Step 1, Ready to Use; 235-mL plastic bottles; 16/case

Features

Our most advanced formula with 2’-FL.^*
2'-FL^* is structurally identical to 2'-FL human milk oligosaccharide (HMO),¹ the most abundant HMO found in the breast milk of most mothers.²
Addition of 2'-FL^* to infant formula may help support the development and regulation of the formula-fed baby's immune response to be closer to that of breastfed infants.^3,†
DHA, the most abundant Omega-3 fatty acid in brain and eyes.⁴
Lutein, an antioxidant found in breast milk and concentrated in the infant brain and eyes.^5,6,7 Recent studies show that lutein may have a role in visual and cognitive development.⁸
Vitamin E, a dietary antioxidant that protects fats in body tissues from oxidation.⁹ Similac Pro-Advance® uses natural vitamin E,^‡ the most abundant form found in breast milk and in the infant brain.^10,11
Non-GMO.^§
Easy to digest.^¶
Gluten-free.
Kosher.
Halal.

PRECAUTIONS

Not for parenteral use.

^* Not derived from human milk.

¹ Weichert S et al. Nutr Res 2013;33(10):831-8.

^† Breast milk is best for babies, contains many immune factors not available in infant formula, and its use is recommended for as long as possible during infancy.

² Castanys-Muñoz E et al. Nutr Rev 2013;71(12):773-89.

^‡ RRR-alpha-tocopherol, the most bioactive form of vitamin E.

³ Goehring KC, et al. J Nutr. 2016;146(12):2559-2566.

^§ Ingredients not genetically engineered.

⁴ Canadian Food Inspection Agency: Health Claims – Nutrient Function Claims. Last modiﬁed on 2019-10-31. [Accessed online on 2023-11-14]

^¶ Similar to other infant formulas.

⁵ Zimmer JP, et al. Clin Ophtalmol. 2007;1:25-35.

⁶ Krinsky NI, et al. Annu Rev Nutr. 2003;23:171-201.

⁷ Vishwanathan R, et al. JPGN. 2014;59(5):659-65.

⁸ Johnson EJ. Nutr Rev. 2014;72(9):605-12.

⁹ Kuchan MJ, et al. Curr Dev Nutr. 2018;2:nzy055

¹⁰ Kuchan MJ, et al. Br J Nutr. 2016;116(1):126-31.

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Preparation

Directions for Use:

Do not add water

Do not use if breakaway ring is missing or broken.

Once feeding begins, use with 1 hour or discard.

WARNING: Do not use the Similac® bottle to warm formula. Never use a microwave oven to warm formula; serious burns can result. Test temperature before feeding to avoid scalding the baby’s mouth.

Wash hands thoroughly with soap and water.
Place washed cups or bottles (if needed), nipples, rings, caps and all preparation equipment in boiling water and keep at a rolling boil for 2 minutes.
SHAKE BOTTLE WELL and twist off cap.
If using a Similac® bottle: Attach sterilized nipple. If using a different feeding container: Pour formula into cups or bottles. If there is formula remaining in the Similac® bottle, refrigerate and use within 48 hours.

Storage

Store unopened bottles under normal room temperature conditions; avoid extreme temperatures. Cover opened or prepared bottles/cups, refrigerate and use within 48 hours. Do not reuse the Similac® bottle. Once feeding begins, use within 1 hour or discard.

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Nutrition

Unflavored Ready to Use

Similac Pro-Advance® Step 1, Ready to Use; 235-mL plastic bottles; 16/case

Serving size: 100 mL

Value

Product Characteristics

Caloric Density (Cal/mL)
0.68

Protein (% of total energy)
8.3

Protein Source
Dry or evaporated skim milk, whey protein concentrate

Fat (% of total energy)
49.3

Omega-6:Omega-3 Ratio
8.12:1

MCT oil (% of total fats)
0

Fat Source
High oleic safflower oil, soy oil, coconut oil, M. alpina oil, C. cohnii oil, monoglycerides, soy lecithin

Carbohydrate (% of total energy)
42.4

Carbohydrate Source
Lactose, fructooligosaccharides, 2’-fucosyllactose

Total Cal:g Nitrogen Ratio
304:1

Nonprotein Cal:g Nitrogen Ratio
277:1

Water (g/L)
904

Osmolality (mOsm/kg water)
306

Renal Solute Load (mOsm/L)
127

Recommended Tube Size for Gravity/Pump Feeding (Fr)
N/A

Amount per Serving

Nutrient Data

ENERGY, Cal (kJ)
68 (280)

Protein, g
1.4

Taurine, mg
4.1

Carnitine, mg
0.82

Tryptophan, mg
22

Fat, g
3.7

Linoleic Acid, g
0.65

Linolenic Acid, g
0.063

Arachidonic Acid (ARA), g
0.017

Docosahexaenoic Acid (DHA), g
0.011

Carbohydrate, g
7.3

Fibre, g
0.18

2'-fucosyllactose (2'-FL), mg
20

Nucleotides, mg
7.2

Vitamins

Inositol, mg
3.8

Lutein, mg
0.0053

Vitamin A, IU
203

Vitamin D, IU
35

Vitamin E, IU
2.5

Vitamin K, mg
0.0083

Vitamin C, mg
9

Thiamine, mg
0.064

Riboflavin, mg
0.11

Niacin, mg
0.45

Vitamin B6, mg
0.054

Folic Acid, mg
0.0095

Vitamin B12, mg
0.00023

Pantothenic Acid, mg
0.4

Biotin, mg
0.0025

Choline, mg
9.8

Minerals

Sodium, mg
18

Potassium, mg
79

Chloride, mg
40

Calcium, mg
53

Phosphorus, mg
26

Magnesium, mg
4.1

Iron, mg
1.1

Zinc, mg
0.45

Iodine, mg
0.0085

Copper, mg
0.047

Manganese, mg
0.004

Selenium, mg
0.0008

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Ingredients

Unflavored Ready to Use

Similac Pro-Advance® Step 1, Ready to Use; 235-mL plastic bottles; 16/case

Contains: Milk, Soy.

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Availability

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

LIST NUMBER

ITEM

6726713

Similac Pro-Advance® Step 1, Ready to Use; 235-mL plastic bottles; 16/case

Features

Our most advanced formula with 2’-FL.^*
2'-FL^* is structurally identical to 2'-FL human milk oligosaccharide (HMO),¹ the most abundant HMO found in the breast milk of most mothers.²
Addition of 2'-FL^* to infant formula may help support the development and regulation of the formula-fed baby's immune response to be closer to that of breastfed infants.^3,†
DHA, the most abundant Omega-3 fatty acid in brain and eyes.⁴
Lutein, an antioxidant found in breast milk and concentrated in the infant brain and eyes.^5,6,7 Recent studies show that lutein may have a role in visual and cognitive development.⁸
Vitamin E, a dietary antioxidant that protects fats in body tissues from oxidation.⁹ Similac Pro-Advance® uses natural vitamin E,^‡ the most abundant form found in breast milk and in the infant brain.^10,11
Non-GMO.^§
Easy to digest.^¶
Gluten-free.
Kosher.
Halal.

PRECAUTIONS

Not for parenteral use.

^* Not derived from human milk.

¹ Weichert S et al. Nutr Res 2013;33(10):831-8.

^† Breast milk is best for babies, contains many immune factors not available in infant formula, and its use is recommended for as long as possible during infancy.

² Castanys-Muñoz E et al. Nutr Rev 2013;71(12):773-89.

^‡ RRR-alpha-tocopherol, the most bioactive form of vitamin E.

³ Goehring KC, et al. J Nutr. 2016;146(12):2559-2566.

^§ Ingredients not genetically engineered.

⁴ Canadian Food Inspection Agency: Health Claims – Nutrient Function Claims. Last modiﬁed on 2019-10-31. [Accessed online on 2023-11-14]

^¶ Similar to other infant formulas.

⁵ Zimmer JP, et al. Clin Ophtalmol. 2007;1:25-35.

⁶ Krinsky NI, et al. Annu Rev Nutr. 2003;23:171-201.

⁷ Vishwanathan R, et al. JPGN. 2014;59(5):659-65.

⁸ Johnson EJ. Nutr Rev. 2014;72(9):605-12.

⁹ Kuchan MJ, et al. Curr Dev Nutr. 2018;2:nzy055

¹⁰ Kuchan MJ, et al. Br J Nutr. 2016;116(1):126-31.

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Preparation

Directions for Use:

Do not add water

Do not use if breakaway ring is missing or broken.

Once feeding begins, use with 1 hour or discard.

WARNING: Do not use the Similac® bottle to warm formula. Never use a microwave oven to warm formula; serious burns can result. Test temperature before feeding to avoid scalding the baby’s mouth.

Wash hands thoroughly with soap and water.
Place washed cups or bottles (if needed), nipples, rings, caps and all preparation equipment in boiling water and keep at a rolling boil for 2 minutes.
SHAKE BOTTLE WELL and twist off cap.
If using a Similac® bottle: Attach sterilized nipple. If using a different feeding container: Pour formula into cups or bottles. If there is formula remaining in the Similac® bottle, refrigerate and use within 48 hours.

Storage

Store unopened bottles under normal room temperature conditions; avoid extreme temperatures. Cover opened or prepared bottles/cups, refrigerate and use within 48 hours. Do not reuse the Similac® bottle. Once feeding begins, use within 1 hour or discard.

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Nutrition

Unflavored Ready to Use

Similac Pro-Advance® Step 1, Ready to Use; 235-mL plastic bottles; 16/case

Serving size: 100 Cal

Value

Product Characteristics

Caloric Density (Cal/mL)
0.68

Protein (% of total energy)
8.3

Protein Source
Dry or evaporated skim milk, whey protein concentrate

Fat (% of total energy)
49.3

Omega-6:Omega-3 Ratio
8.12:1

MCT oil (% of total fats)
0

Fat Source
High oleic safflower oil, soy oil, coconut oil, M. alpina oil, C. cohnii oil, monoglycerides, soy lecithin

Carbohydrate (% of total energy)
42.4

Carbohydrate Source
Lactose, fructooligosaccharides, 2’-fucosyllactose

Total Cal:g Nitrogen Ratio
304:1

Nonprotein Cal:g Nitrogen Ratio
277:1

Water (g/L)
904

Osmolality (mOsm/kg water)
306

Renal Solute Load (mOsm/L)
127

Recommended Tube Size for Gravity/Pump Feeding (Fr)
N/A

Amount per Serving

Nutrient Data

ENERGY, Cal (kJ)
100 (419)

Protein, g
2.07

Taurine, mg
6.07

Carnitine, mg
1.2

Tryptophan, mg
33.1

Fat, g
5.49

Linoleic Acid, g
0.966

Linolenic Acid, g
0.093

Arachidonic Acid (ARA), g
0.025

Docosahexaenoic Acid (DHA), g
0.016

Carbohydrate, g
10.8

Fibre, g
0.27

2'-fucosyllactose (2'-FL), mg
30

Nucleotides, mg
10.7

Vitamins

Inositol, mg
5.6

Lutein, mg
0.0078

Vitamin A, IU
300

Vitamin D, IU
51.8

Vitamin E, IU
3.7

Vitamin K, mg
0.0123

Vitamin C, mg
13.3

Thiamine, mg
0.0947

Riboflavin, mg
0.163

Niacin, mg
0.666

Vitamin B6, mg
0.0799

Folic Acid, mg
0.0141

Vitamin B12, mg
0.00034

Pantothenic Acid, mg
0.59

Biotin, mg
0.0037

Choline, mg
14.5

Minerals

Sodium, mg
26.6

Potassium, mg
117

Chloride, mg
59.2

Calcium, mg
78.4

Phosphorus, mg
38.5

Magnesium, mg
6.1

Iron, mg
1.63

Zinc, mg
0.67

Iodine, mg
0.0126

Copper, mg
0.0695

Manganese, mg
0.0059

Selenium, mg
0.00118

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Ingredients

Unflavored Ready to Use

Similac Pro-Advance® Step 1, Ready to Use; 235-mL plastic bottles; 16/case

Contains: Milk, Soy.

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

SIMILAC PRO-ADVANCE^® STEP 1 READY TO USE

with 2'-FL oligosaccharide / DHA- and ARA-fortified

Availability

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PRECAUTIONS

Preparation

Nutrition

Ingredients

Availability

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PRECAUTIONS

Preparation

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Preparation

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Ingredients

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Preparation

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Ingredients

For health care professionals

Site Pages

Abbott

SIMILAC PRO-ADVANCE® STEP 1 READY TO USE

with 2'-FL oligosaccharide / DHA- and ARA-fortified

Availability

Features

PRECAUTIONS

Preparation

Nutrition

Ingredients

Availability

Features

PRECAUTIONS

Preparation

Nutrition

Ingredients

Availability

Features

PRECAUTIONS

Preparation

Nutrition

Ingredients

Availability

Features

PRECAUTIONS

Preparation

Nutrition

Ingredients

For health care professionals

Site Pages

Abbott

SIMILAC PRO-ADVANCE^® STEP 1 READY TO USE